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"Twenty-five years feels right in my bones and it feels right in my spirit. It's the perfect number. It's the exact right time," Oprah Winfrey told her live audience on Friday, the day after the head of Harpo announced that the talk-show legend's last show would air on Sept. 9, 2011. "This show has been my life, and I love it enough to know when it's time to say goodbye," Oprah said through tears and a breaking voice. Oprah thanked her viewers for letting her into their "living rooms" and "lives" and said that she plans to go out with a bang. "We are going to knock your socks off," she said. "The countdown to the end of The Oprah Winfrey Show starts now." Oprah's departure leaves big questions in its wake: Where will the talk-show maven go? Could anyone ever replace her? "She has been one of the family for Americans for 25 years," The Daily Beast editor Tina Brown told Good Morning America Friday. "The audience is just going to have to follow her, right?"