0Regis Philbin's BFF Smackdown Who’s better friends with Regis Philbin—Jerry Seinfeld or David Letterman? The two faced off for the title of ultimate BFF on the ‘Late Show’ Wednesday while discussing Seinfeld’s article in this week’s Newsweek.Updated Apr. 24, 2017 2:17PM EDT / Published Nov. 17, 2011 8:36AM EST CBS