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A man walks past Pfizer's world headquarters in New York April 28, 2014. U.S. drugmaker Pfizer Inc approached Britain's AstraZeneca Plc two days ago to reignite a potential $100 billion takeover and was rebuffed, raising investor expectations it will have to increase its offer to close the deal. REUTERS/Andrew Kelly (UNITED STATES - Tags: BUSINESS HEALTH LOGO) - RTR3MZSH Andrew Kelly/Reuters