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One person not applauding President Obama’s Cairo speech? The Ayatollah Ali Khamenei, the Supreme Leader of Iran. Reacting to Obama’s speech, Khamenei said "Even if they give sweet and beautiful talks to the Muslim nation ... that will not create a change. Nothing will change with speeches and slogans." He called Israel a “cancerous tumor in the heart [of the Muslim world]”, and said "The nations of this part of the world ... deeply hate America because during many years they have seen violence, military interference, rights violations, discrimination ... from America.”