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Oprah has a big guest for one of her final shows: First Lady Michelle Obama will tape an interview appearance on The Oprah Winfrey Show, where she will discuss her campaign to boost support for military families. The episode is scheduled to air on Thursday, January 27, and it will mark the first time Oprah has seen the first lady since December 2009 when she taped her annual holiday special at the White House and interviewed both Michelle and President Obama.