As Sarah Palin contemplates how best to increase her national profile, Alaska's other leading lady, Sen. Lisa Murkowski, has some words of warning: Keep your hands off my Senate seat. Palin could challenge Murkowski in 2010, as a Senate seat would give her a national platform, a thicker resume, and a chance to beef up on foreign policy. "If she wants to be president, I don't think the way to the presidency is a short stop in the United States Senate," Murkowski tells Politico. If Palin lost, she would damage her chances at the GOP nomination in 2012. "I can guarantee it would be a very tough election," Murkowski says. Palin defeated Murkowski’s father, Frank, in the 2006 GOP Republican primary.