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Commissioner of the U.S. Food and Drug Administration Margaret Hamburg is reportedly stepping down, Reuters said Thursday, citing a source briefed on the matter. The White House is expected to announce Hamburg’s resignation Friday, but FDA spokeswoman Stephanie Yao declined to comment. The 59-year-old has been at the helm of the FDA for almost six years, one of the longest-serving commissioners in the modern era. Hamburg has spearheaded public-health initiatives including restricting tobacco use and drug approvals and previously served at the National Institutes of Health before becoming New York City’s health commissioner.