At least 43 people were killed and dozens more injured after a passenger train crashed into an oncoming freight train near northern Thessaly in Greece late Tuesday, fire officials said. Around 350 passengers were thought to have been on board and the crash was “mainly due to a tragic human error,” Greek Prime Minister Kyriakos Mitsotakis said. At least 20 ambulances and 150 firefighters were on the smoke-clogged scene, Greek Fire Service spokesman Vassilis Varthakogiannis said. The impact was described as “very strong” by regional governor Konstantinos Agorastos, who told SKAI TV that the passenger train’s first four carriages had derailed, and that the first two were “almost completely” destroyed. People in the train’s front cars were reportedly flung out on impact and found more than 130 feet away, while others remained trapped in the burning wreckage. Greek Transportation Minister Kostas Karamanlis resigned on Wednesday out of “respect for the memory of the people who died so unfairly,” he said, and three days of mourning have been declared.